Center for Advancing Risk Assessment Science and Policy (ARASP)

Methods for Conducting MOA Analysis and Use of MOA in Risk Assessment

• Biologically Motivated Computational Modeling: Contribution to Risk Assessment
• Recent Developments in Frameworks to Consider Human Relevance of Hypothesized Modes of Action for Tumours in Animals
• The Vanishing Zero Revisited: Thresholds in the Age of Genomics
• Development of a Quantitative Model Incorporating Key Events in a Hepatotoxic Mode of Action to Predict Tumor Incidence
• Systems Biology and Mode of Action Based Risk Assessment
• A Risk Assessment Perspective: Application of Mode of Action and Human Relevance Frameworks to the Analysis of Rodent Tumor Data

Evaluating Relevance of Different Modes of Action to Humans

• Mode of Action in Relevance of Rodent Liver Tumors to Human Cancer Risk
• Evaluating the Human Relevance of Chemically Induced Animal Tumors
• Case Study: An Evaluation of the Human Relevance of the Synthetic Pyrethroid Metofluthrin-Induced Liver Tumors in Rats Based on Mode of Action
• Hemangiosarcoma in Rodents: Mode-of-Action Evaluation and Human Relevance
• Mode-of-Action Framework for Evaluating the Relevance of Rodent Forestomach Tumors in Cancer Risk Assessment

Modes of Action of Specific Chemicals

• Proposed Mode of Action of Benzene-Induced Leukemia: Interpreting Available Data and Identifying Critical Data Gaps for Risk Assessment
• Arsenic-Induced Carcinogenesis—Oxidative Stress as a Possible Mode of Action and Future Research Needs for More Biologically Based Risk Assessment
• Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation
• Perfluoroalkyl Acids and Related Chemistries—Toxicokinetics and Modes of Action
• Thiamethoxam Induced Mouse Liver Tumors and Their Relevance to Humans: Part 1: Mode of Action Studies in the Mouse
• Evaluation of Potential Modes of Action of Inhaled Ethylbenzene in Rats and Mice
• Cytotoxicity and Regenerative Proliferation as the Mode of Action for Diuron-Induced Urothelial Carcinogenesis in the Rat
• Trichloroethylene-Induced Mouse Lung Tumors: Studies of the Mode of Action and Comparisons between Species
• A Systems-Based Computational Model for Dose-Response Comparisons of Two Mode of Action Hypotheses for Ethanol-Induced Neurodevelopmental Toxicity
• Mode of Action and Pharmacokinetic Studies of 2-Butoxyethanol in the Mouse with an Emphasis on Forestomach Dosimetry
• Estimates of Cancer Potency of 2,3,4,7,8-Pentachlorodibenzofuran Using Both Nonlinear and Linear Approaches